Publications

Lab members in bold

2024 and before

2025

Featured

The human Y and inactive X chromosomes similarly modulate autosomal gene expression

The human Y and inactive X chromosomes similarly modulate autosomal gene expression

San Roman, A.K., Skaletsky, H., Godfrey, A.K., Bokil, N.V., Teitz, L., Singh, I., Blanton, L.V., Bellott, D.W., Pyntikova, T., Lange, J., Koutseva, N., Hughes, J.F., Brown, L., Phou, S., Buscetta, A., Kruszka, P., Banks, N., Dutra, A., Pak, E., Lasutschinkow, P.C., Keen, C., Davis, S.M., Lin, A.E., Tartaglia, N.R., Samango-Sprouse, C., Muenke, M., Page, D.C. (2024) Cell Genomics 4(1): 100462.

[HTML] [PDF] [Data] [Code]

Adrianna’s Tweetorial

[Whitehead News: Sex chromosomes responsible for much more than determining sex]

Read More →

The human inactive X chromosome modulates expression of the active X chromosome

The human inactive X chromosome modulates expression of the active X chromosome

San Roman, A.K., Godfrey, A.K., Skaletsky, H., Bellot, D.W., Groff, A.F., Bokil, N.V., Harris, H.L., Blanton, L.V., Hughes, J.F., Brown, L., Phou, S., Koutseva, N., Buscetta, A., Kruszka, P., Banks, N., Dutra, A., Pak, E., Lasutschinkow, P.C., Keen, C., Davis, S.M., Tartaglia, N.R., Samango-Sprouse, C., Muenke, M., and Page, D.C. (2023) Cell Genomics. 3(2): 100259.

Article featured on Cell Genomics cover!

[HTML] [PDF] [Data] [Code]

[Whitehead News: Not so inactive X chromosome]

[Whitehead News: Inactive X chromosome moves from second fiddle to the conductor’s podium]

Read More →

Genetic counseling for women with 45,X/46,XX mosaicism: Towards more personalized management

Genetic counseling for women with 45,X/46,XX mosaicism: Towards more personalized management

Snyder, E.A., San Roman, A.K., Piña-Aguilar, R.E., Stevens, M.A., McNamara, E.M., Hayes, F.J., Levitsky, L.L., Lin, A.E. (2021) Eur. J. Med. Genet. 64(3): 104140.

Read More →

A strategic research alliance: Turner syndrome and sex differences

A strategic research alliance: Turner syndrome and sex differences

San Roman, A.K. and Page, D.C. (2019) Am. J. Med. Genet. Part C. 181C: 92-100.

Read More →

“Donating our bodies to science”: A discussion about autopsy and organ donation in Turner Syndrome

“Donating our bodies to science”: A discussion about autopsy and organ donation in Turner Syndrome

Prakash, K.S., San Roman, A.K., Crenshaw, M., Flink, B., Earle, K., Los, E., Bonnard, A., Lin, A.E. (2019) Am. J. Med. Genet. Part C. 181C: 22-28.

Read More →

Transcription factor-dependent “anti-repressive” mammalian enhancers exclude H3K27me3 from extended domains

Transcription factor-dependent “anti-repressive” mammalian enhancers exclude H3K27me3 from extended domains

Saxena, M., San Roman, A.K., O’Neill, N.K., Sulahian, R., Jadhav, U., and Shivdasani, R.A. (2018) Genes Dev. 31: 2391-2404.

Read More →

ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice

ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice

Mathur, R., Alver, B.H., San Roman, A.K., Wilson, B.G., Wang, X., Agoston, A.T., Park, P.J., Shivdasani, R.A., and Roberts, C.M. (2017) Nat. Genet. 49: 296-302.

Read More →

The Alimentary Canal

The Alimentary Canal

San Roman, A.K., Kim, T.-H., and Shivdasani, R.A. In: Baldock, R., Bard, J., Davidson, D., Morriss-Kay, G., eds. Kaufman’s Atlas of Mouse Development Supplement: With Coronal Sections. Amsterdam: Elsevier, 2016; Ch. 5, p. 77-84.

Read More →

Distinct processes and transcriptional targets underlie CDX2 requirements in intestinal stem cells and differentiated villus cells

Distinct processes and transcriptional targets underlie CDX2 requirements in intestinal stem cells and differentiated villus cells

San Roman, A.K., Tovaglieri, A., Breault, D.T., and Shivdasani, R.A. (2015) Stem Cell Rep. 5: 673-81.

Read More →

Transcription Factors GATA4 and HNF4A Control Distinct Aspects of Intestinal Homeostasis in Conjunction with Transcription Factor CDX2

Transcription Factors GATA4 and HNF4A Control Distinct Aspects of Intestinal Homeostasis in Conjunction with Transcription Factor CDX2

San Roman, A.K., Aaronson, B.E., Krasinski, S.D., Shivdasani, R.A., and Verzi, M.P. (2015) J. Biol. Chem. 290: 1850-1860.

Read More →

Dissecting engineered cell types and enhancing cell fate conversion via CellNet

Dissecting engineered cell types and enhancing cell fate conversion via CellNet

Morris, S.A., Cahan, P., Li, H., Zhao, A.M., San Roman, A.K., Shivdasani, R.A., Collins, J.J., and Daley, G.Q. (2014). Cell. 158: 889–902.

Read More →

Wnt secretion from epithelial cells and subepithelial myofibroblasts is not required in the mouse intestinal stem cell niche in vivo.

Wnt secretion from epithelial cells and subepithelial myofibroblasts is not required in the mouse intestinal stem cell niche in vivo.

San Roman, A.K.*, Jayewickreme, C.J.*, Murtaugh, L.C., and Shivdasani, R.A. (2014) Stem Cell Rep. 2: 127-134.

*Co-first authors

Read More →

Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding

Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding

Verzi, M.P.*, Shin, H.*, San Roman, A.K., Liu, S., and Shivdasani, R.A. (2013) Mol. Cell Biol. 33: 281-292.

*Co-first authors

Read More →

Boundaries, junctions and transitions in the gastrointestinal tract

Boundaries, junctions and transitions in the gastrointestinal tract

San Roman, A.K. and Shivdasani, R.A. (2011) Exp. Cell Res. 317: 2711-18.

Read More →

BZL101, a phytochemical extract from the Scutelleria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype

BZL101, a phytochemical extract from the Scutelleria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype

Marconett, C.N., Morgenstern, T.J., San Roman, A.K., Sundar, S.N., Singhal, A.K. and Firestone, G.L. (2010) Cancer Biol. Ther. 10: 397-405.

Read More →

Control of Arabidopsis meristem development by thioredoxin-dependent regulation of intercellular transport

Control of Arabidopsis meristem development by thioredoxin-dependent regulation of intercellular transport

Benitez-Alfonso, Y., Cilia, M., San Roman, A., Thomas, C., Maule, A., Hearn, S., Jackson, D. (2009) Proc. Natl. Acad. Sci. U.S.A. 106: 3615-3620.

Read More →

Role of phosphopantetheinyl transferase genes in antibiotic production by Streptomyces coelicolor

Role of phosphopantetheinyl transferase genes in antibiotic production by Streptomyces coelicolor

Lu, Y.W., San Roman, A.K. and Gehring, A.M. (2008) J. Bacteriol. 190: 6903-8.

Read More →

2024 and before

Featured

The human Y and inactive X chromosomes similarly modulate autosomal gene expression

The human Y and inactive X chromosomes similarly modulate autosomal gene expression

San Roman, A.K., Skaletsky, H., Godfrey, A.K., Bokil, N.V., Teitz, L., Singh, I., Blanton, L.V., Bellott, D.W., Pyntikova, T., Lange, J., Koutseva, N., Hughes, J.F., Brown, L., Phou, S., Buscetta, A., Kruszka, P., Banks, N., Dutra, A., Pak, E., Lasutschinkow, P.C., Keen, C., Davis, S.M., Lin, A.E., Tartaglia, N.R., Samango-Sprouse, C., Muenke, M., Page, D.C. (2024) Cell Genomics 4(1): 100462.

[HTML] [PDF] [Data] [Code]

Adrianna’s Tweetorial

[Whitehead News: Sex chromosomes responsible for much more than determining sex]

Read More →

The human inactive X chromosome modulates expression of the active X chromosome

The human inactive X chromosome modulates expression of the active X chromosome

San Roman, A.K., Godfrey, A.K., Skaletsky, H., Bellot, D.W., Groff, A.F., Bokil, N.V., Harris, H.L., Blanton, L.V., Hughes, J.F., Brown, L., Phou, S., Koutseva, N., Buscetta, A., Kruszka, P., Banks, N., Dutra, A., Pak, E., Lasutschinkow, P.C., Keen, C., Davis, S.M., Tartaglia, N.R., Samango-Sprouse, C., Muenke, M., and Page, D.C. (2023) Cell Genomics. 3(2): 100259.

Article featured on Cell Genomics cover!

[HTML] [PDF] [Data] [Code]

[Whitehead News: Not so inactive X chromosome]

[Whitehead News: Inactive X chromosome moves from second fiddle to the conductor’s podium]

Read More →

Genetic counseling for women with 45,X/46,XX mosaicism: Towards more personalized management

Genetic counseling for women with 45,X/46,XX mosaicism: Towards more personalized management

Snyder, E.A., San Roman, A.K., Piña-Aguilar, R.E., Stevens, M.A., McNamara, E.M., Hayes, F.J., Levitsky, L.L., Lin, A.E. (2021) Eur. J. Med. Genet. 64(3): 104140.

Read More →

A strategic research alliance: Turner syndrome and sex differences

A strategic research alliance: Turner syndrome and sex differences

San Roman, A.K. and Page, D.C. (2019) Am. J. Med. Genet. Part C. 181C: 92-100.

Read More →

“Donating our bodies to science”: A discussion about autopsy and organ donation in Turner Syndrome

“Donating our bodies to science”: A discussion about autopsy and organ donation in Turner Syndrome

Prakash, K.S., San Roman, A.K., Crenshaw, M., Flink, B., Earle, K., Los, E., Bonnard, A., Lin, A.E. (2019) Am. J. Med. Genet. Part C. 181C: 22-28.

Read More →

Transcription factor-dependent “anti-repressive” mammalian enhancers exclude H3K27me3 from extended domains

Transcription factor-dependent “anti-repressive” mammalian enhancers exclude H3K27me3 from extended domains

Saxena, M., San Roman, A.K., O’Neill, N.K., Sulahian, R., Jadhav, U., and Shivdasani, R.A. (2018) Genes Dev. 31: 2391-2404.

Read More →

ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice

ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice

Mathur, R., Alver, B.H., San Roman, A.K., Wilson, B.G., Wang, X., Agoston, A.T., Park, P.J., Shivdasani, R.A., and Roberts, C.M. (2017) Nat. Genet. 49: 296-302.

Read More →

The Alimentary Canal

The Alimentary Canal

San Roman, A.K., Kim, T.-H., and Shivdasani, R.A. In: Baldock, R., Bard, J., Davidson, D., Morriss-Kay, G., eds. Kaufman’s Atlas of Mouse Development Supplement: With Coronal Sections. Amsterdam: Elsevier, 2016; Ch. 5, p. 77-84.

Read More →

Distinct processes and transcriptional targets underlie CDX2 requirements in intestinal stem cells and differentiated villus cells

Distinct processes and transcriptional targets underlie CDX2 requirements in intestinal stem cells and differentiated villus cells

San Roman, A.K., Tovaglieri, A., Breault, D.T., and Shivdasani, R.A. (2015) Stem Cell Rep. 5: 673-81.

Read More →

Transcription Factors GATA4 and HNF4A Control Distinct Aspects of Intestinal Homeostasis in Conjunction with Transcription Factor CDX2

Transcription Factors GATA4 and HNF4A Control Distinct Aspects of Intestinal Homeostasis in Conjunction with Transcription Factor CDX2

San Roman, A.K., Aaronson, B.E., Krasinski, S.D., Shivdasani, R.A., and Verzi, M.P. (2015) J. Biol. Chem. 290: 1850-1860.

Read More →

Dissecting engineered cell types and enhancing cell fate conversion via CellNet

Dissecting engineered cell types and enhancing cell fate conversion via CellNet

Morris, S.A., Cahan, P., Li, H., Zhao, A.M., San Roman, A.K., Shivdasani, R.A., Collins, J.J., and Daley, G.Q. (2014). Cell. 158: 889–902.

Read More →

Wnt secretion from epithelial cells and subepithelial myofibroblasts is not required in the mouse intestinal stem cell niche in vivo.

Wnt secretion from epithelial cells and subepithelial myofibroblasts is not required in the mouse intestinal stem cell niche in vivo.

San Roman, A.K.*, Jayewickreme, C.J.*, Murtaugh, L.C., and Shivdasani, R.A. (2014) Stem Cell Rep. 2: 127-134.

*Co-first authors

Read More →

Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding

Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding

Verzi, M.P.*, Shin, H.*, San Roman, A.K., Liu, S., and Shivdasani, R.A. (2013) Mol. Cell Biol. 33: 281-292.

*Co-first authors

Read More →

Boundaries, junctions and transitions in the gastrointestinal tract

Boundaries, junctions and transitions in the gastrointestinal tract

San Roman, A.K. and Shivdasani, R.A. (2011) Exp. Cell Res. 317: 2711-18.

Read More →

BZL101, a phytochemical extract from the Scutelleria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype

BZL101, a phytochemical extract from the Scutelleria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype

Marconett, C.N., Morgenstern, T.J., San Roman, A.K., Sundar, S.N., Singhal, A.K. and Firestone, G.L. (2010) Cancer Biol. Ther. 10: 397-405.

Read More →

Control of Arabidopsis meristem development by thioredoxin-dependent regulation of intercellular transport

Control of Arabidopsis meristem development by thioredoxin-dependent regulation of intercellular transport

Benitez-Alfonso, Y., Cilia, M., San Roman, A., Thomas, C., Maule, A., Hearn, S., Jackson, D. (2009) Proc. Natl. Acad. Sci. U.S.A. 106: 3615-3620.

Read More →

Role of phosphopantetheinyl transferase genes in antibiotic production by Streptomyces coelicolor

Role of phosphopantetheinyl transferase genes in antibiotic production by Streptomyces coelicolor

Lu, Y.W., San Roman, A.K. and Gehring, A.M. (2008) J. Bacteriol. 190: 6903-8.

Read More →