Laboratory of sex differences in human biology
Established 2024 at Duke University School of Medicine
Department of Molecular Genetics and Microbiology
Center for Advanced Genomics Technologies
Welcome
There are widespread sex differences in human phenotypes, but their causes remain poorly understood. Our goal is to define the molecular mechanisms driving sex differences in human biology to advance healthcare across the spectrum of sex.
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What we do and why we do it
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How we do science
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Who is on the team
Featured publications
Alexis LaRosa joins the lab as a PhD student!
1/6/26 Alexis is an MD/PhD student originally from Long Beach, Mississippi. She received her BS in Cellular and Molecular Biology from Tulane University in 2023. During her time at Tulane, Alexis was a member of the Belancio lab, where she studied the relationship between LINE-1 transposon expression and exposure to light at night. Outside of lab, Alexis enjoys traveling, learning new languages, and indoor cycling. Welcome, Alexis!
Lab News
The lab turns two!
1/2/26 Our second year was full of lab milestones! Our first graduate students and postdocs joined the lab to work on exciting new projects (more on those this year)! Our first two lab alumni were accepted into PhD programs! Two lab members received fellowships for graduate and postdoctoral training! We presented our science near and far, wrote our first review article (coming soon), and started a new science communication initiative! Cheers to a great year and a bright future for the lab!
Schuyler Melore joins the lab as a postdoc!
12/31/25 Schuyler is a postdoctoral associate originally from Long Island, NY. He received a bachelor's degree in mathematics from Williams College in 2017 and then pivoted to biomedical research by joining the Chavez Lab at Columbia University as a lab technician. There, he worked to develop new CRISPR tools for precision genome editing and workflows for hard-to-screen phenotypes. In 2020, he came to Duke to pursue a PhD in genetics and genomics in Dr. Tim Reddy's lab, where he mainly worked on applying Cas12a technology to epigenome editing screens. Schuyler is excited to join the San Roman lab and continue to develop CRISPR tools and methods to interrogate the genetic underpinnings of sex-biased diseases as well as those caused by sex chromosome aneuploidies. Outside the lab, you can find him hiking, playing the tuba, and hanging out with his two cats. Welcome, Schuyler!