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As reported in this issue of Cell Genomics, San Roman et al. harnessed this variation to discover that the “inactive” X chromosome regulates expression of the “active” X chromosome. The cover is inspired by Andy Warhol’s 1960s pop art paintings, which were produced contemporaneously with the discovery of X chromosome inactivation, the premier example of epigenetic regulation. As shown here, the “inactive” X chromosome can be visualized as a heterochromatic density at the nuclear periphery that is known as the “Barr body”. The cells here depict the range of X chromosome copy number interrogated in the present study – from one to four. Since all but one X chromosome is inactivated in each cell, this is visualized as zero to three Barr bodies (inactive X chromosomes). Illustration by Caitlin Rausch. https://www.sanromanlab.com/publications-database/kabeuv18ab70g9ixo46uffbbc1bnfk-b5kp9-377ab-944l5-ajm4h-hhf5d-c6jld-l6wst-gghzh-fhw4a-t4ywr-jbysf-4njk9-n69fh-7ah7y monthly 0.5 2023-08-25 https://www.sanromanlab.com/publications-database/kabeuv18ab70g9ixo46uffbbc1bnfk-b5kp9-377ab-944l5-ajm4h-hhf5d-c6jld-l6wst-gghzh-fhw4a-t4ywr-jbysf-4njk9-n69fh monthly 0.5 2025-07-13 https://www.sanromanlab.com/publications-database/kabeuv18ab70g9ixo46uffbbc1bnfk-b5kp9-377ab-944l5-ajm4h-hhf5d-c6jld-l6wst-gghzh-fhw4a-t4ywr-jbysf-4njk9 monthly 0.5 2023-08-25 https://www.sanromanlab.com/publications-database/kabeuv18ab70g9ixo46uffbbc1bnfk-b5kp9-377ab-944l5-ajm4h-hhf5d-c6jld-l6wst-gghzh-fhw4a-t4ywr-jbysf monthly 0.5 2023-08-25 https://www.sanromanlab.com/publications-database/kabeuv18ab70g9ixo46uffbbc1bnfk-b5kp9-377ab-944l5-ajm4h-hhf5d-c6jld-l6wst-gghzh-fhw4a-t4ywr monthly 0.5 2023-08-25 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